Louisville vs. Cincinnati: Point Spread Analysis

Friday Nov 21, 2025 6:30 pm - Cincinnati, OH (Neutral Site)
Odds: Louisville by 8.5, Total Points: 164

Matchup Menu: LOU vs. CIN

More Games From Nov 21, 2025

ATS Predictions

Pick Model Confidence
Cincinnati +8.5 Official TR Pick Cincinnati 52% odds to cover
Cincinnati +8.5 Power Rating Model Cincinnati 65% odds to cover
Cincinnati +8.5 Similar Games Cincinnati 53% odds to cover
Cincinnati +8.5 Decision Tree Cincinnati 52% odds to cover
Cincinnati +8.5 Predictive Ratings Cincinnati 51% odds to cover

ATS Situational Trends

Record LOU adv CIN
Season 16-17-0 14-19-0
vs Division 0-0-0 0-0-0
vs Conference 7-13-0 9-11-0
Streak L2 L3
Last 5 2-3-0 2-3-0
Last 10 4-6-0 5-5-0
Home 10-7-0 10-8-0
Away 6-10-0 4-11-0

Louisville Detailed ATS Performance

Date H/A/N Opponent Line Result +/-
11/03 Home S Carolina St -36.5 W by 59 +22.5
11/06 Home Jackson St -38.5 W by 36 -2.5
11/11 Home Kentucky -6.0 W by 8 +2.0
11/15 Home Ohio -31.0 W by 25 -6.0
11/21 Neutral Cincinnati -8.5 W by 10 +1.5
11/24 Home E Michigan -33.5 W by 41 +7.5
11/26 Home NJIT -43.5 W by 57 +13.5
12/03 Away Arkansas -2.0 L by 9 -11.0
12/06 Neutral Indiana -4.0 W by 9 +5.0
12/13 Home Memphis -16.5 W by 26 +9.5
12/16 Away Tennessee +4.5 L by 21 -16.5
12/20 Home Montana -30.5 W by 40 +9.5
12/30 Away California -7.5 W by 20 +12.5
01/02 Away Stanford -7.0 L by 4 -11.0
01/06 Home Duke (Pick) L by 11 -11.0
01/10 Home Boston College -21.0 W by 13 -8.0
01/13 Home Virginia -4.5 L by 9 -13.5
01/17 Away Pittsburgh -7.0 W by 41 +34.0
01/24 Home Virginia Tech -13.5 W by 14 +0.5
01/26 Away Duke +8.5 L by 31 -22.5
01/31 Home SMU -9.5 W by 14 +4.5
02/04 Home Notre Dame -18.0 W by 11 -7.0
02/07 Away Wake Forest -9.5 W by 8 -1.5
02/09 Home NC State -7.5 W by 41 +33.5
02/14 Neutral Baylor -7.0 W by 11 +4.0
02/17 Away SMU -4.0 L by 10 -14.0
02/21 Home Georgia Tech -23.0 W by 17 -6.0
02/23 Away North Carolina -3.5 L by 3 -6.5
02/28 Away Clemson -2.5 L by 5 -7.5
03/03 Home Syracuse -14.5 W by 15 +0.5
03/07 Away Miami +1.5 W by 3 +4.5
03/11 Neutral SMU -6.5 W by 4 -2.5
03/12 Neutral Miami -1.5 L by 5 -6.5

Cincinnati Detailed ATS Performance

Date H/A/N Opponent Line Result +/-
11/03 Home W Carolina -22.0 W by 31 +9.0
11/07 Home Georgia St -29.5 W by 10 -19.5
11/11 Home Dayton -6.0 W by 12 +6.0
11/16 Home Mt St Mary's -25.5 W by 17 -8.5
11/21 Neutral Louisville +8.5 L by 10 -1.5
11/24 Home NJIT -34.5 W by 27 -7.5
11/26 Home E Michigan -22.5 L by 8 -30.5
12/01 Home Tarleton St -25.0 W by 18 -7.0
12/05 Away Xavier -1.0 L by 5 -6.0
12/13 Neutral Georgia +5.5 L by 19 -13.5
12/17 Home Alabama St -21.0 W by 37 +16.0
12/21 Neutral Clemson +3.5 L by 3 +0.5
12/29 Home Lipscomb -13.5 W by 27 +13.5
01/03 Home Houston +5.0 L by 7 -2.0
01/06 Away West Virginia (Pick) L by 2 -2.0
01/11 Away UCF +2.5 L by 1 +1.5
01/14 Home Colorado -8.5 W by 9 +0.5
01/17 Home Iowa St +5.0 W by 9 +14.0
01/21 Away Arizona +13.5 L by 26 -12.5
01/24 Away Arizona St -2.5 L by 14 -16.5
01/28 Home Baylor -4.5 W by 10 +5.5
01/31 Away Houston +14.5 L by 22 -7.5
02/05 Home West Virginia -5.5 L by 5 -10.5
02/08 Home UCF -4.5 W by 20 +15.5
02/11 Away Kansas St -2.5 W by 29 +26.5
02/15 Home Utah -11.5 W by 4 -7.5
02/21 Away Kansas +8.5 W by 16 +24.5
02/24 Away Texas Tech +6.5 L by 12 -5.5
02/28 Home Oklahoma St -9.5 W by 23 +13.5
03/03 Home BYU -1.5 W by 22 +20.5
03/07 Away TCU +2.5 L by 10 -7.5
03/10 Neutral Utah -12.5 W by 7 -5.5
03/11 Neutral UCF -2.5 L by 1 -3.5